Pub. Date : 2007 Nov 1
PMID : 17823933
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paclitaxel enhanced radiation sensitization for the suppression of human prostate cancer tumor growth via a p53 independent pathway. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | BACKGROUND: This study investigated the influence of p53 status on treatment using combined paclitaxel and irradiation for human prostate cancer (PC) in vitro and in vivo. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | METHODS: Enhancement of the radiation response by paclitaxel was determined by MTT and clonogenic assays in four sublines of the human PC cell line, LNCaP, stably transfected to express different p53 mutations found in PC patients. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | RESULTS: Paclitaxel (8-10 nM) suppressed cell proliferation by 50% by inducing G2M mitotic arrest in LNCaP cell lines transfected to overexpress wild-type or mutant p53. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 5 | CONCLUSIONS: Pre-treatment with paclitaxel enhances radiation efficacy on cell killing and suppression of growth of human PC cell lines in vitro and in vivo via p53 independent pathways. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 6 | Paclitaxel has potential for use as a radiosensitizer in the treatment of patients with PC with either wild-type or mutant p53 genetic status. | Paclitaxel | tumor protein p53 | Homo sapiens |