Title : Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.

Pub. Date : 2007 Nov

PMID : 17785433






1 Functional Relationships(s)
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1 This study reports the previously unsuspected collaboration between HIF-1 and dysregulated MYC and thereby provides additional insights into the regulation of VEGF and the Warburg effect, which describes the propensity for cancer cells to convert glucose to lactate. Lactic Acid MYC proto-oncogene, bHLH transcription factor Homo sapiens