Title : Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells.

Pub. Date : 2008 Jan 30

PMID : 17767925






4 Functional Relationships(s)
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Protein Name
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1 Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate resulted in significant suppression of TPA-induced COX-2 expression. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 PD98059 (ERK inhibitor) and SB203580 (p38 MAPK inhibitor) down-regulated the COX-2 expression induced by TPA. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
3 Furthermore, TPA-induced COX-2 induction as well as NF-kappaB activation was blocked in MCF10A cells transfected with dominant negative mutant ERK1/2 or p38 MAPK. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
4 These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA-stimulated human mammary epithelial cells. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens