Pub. Date : 2008 Apr
PMID : 17767813
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: Deferoxamine, an iron chelator, is reported to induce hypoxia-inducible factor 1 (HIF-1) that leads to transcriptional activation of numerous genes including vascular endothelial growth factor (VEGF) that is known to increase blood-brain barrier (BBB) permeability. | Deferoxamine | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | OBJECTIVE: Deferoxamine, an iron chelator, is reported to induce hypoxia-inducible factor 1 (HIF-1) that leads to transcriptional activation of numerous genes including vascular endothelial growth factor (VEGF) that is known to increase blood-brain barrier (BBB) permeability. | Deferoxamine | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | This study was performed to test whether deferoxamine would disrupt BBB further in focal cerebral ischemia by altering the level of VEGF. | Deferoxamine | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | The number of areas that were stained with VEGF antibody in the deferoxamine 18 group (106 +/- 5/mm2) was significantly higher than that in the control group (54 +/- 2/mm2) or deferoxamine 48 group (58 +/- 1/mm2). | Deferoxamine | vascular endothelial growth factor A | Rattus norvegicus |
| 5 | DISCUSSION: Our data suggest that deferoxamine induced an increase in VEGF but that its effect depends on the time of administration. | Deferoxamine | vascular endothelial growth factor A | Rattus norvegicus |
| 6 | The increase in VEGF by deferoxamine could aggravate the disruption of BBB in focal cerebral ischemia. | Deferoxamine | vascular endothelial growth factor A | Rattus norvegicus |