Title : Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression.

Pub. Date : 2007 Sep

PMID : 17767149






7 Functional Relationships(s)
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1 Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
2 Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
3 Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
4 Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
5 Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
6 Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
7 These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens