Pub. Date : 2007 Oct
PMID : 17760719
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, we demonstrated that capsaicin inhibited the release of pro-inflammatory cytokine, interleukin-8 (IL-8) by H. pylori-infected gastric epithelial cells through nuclear factor-kappaB (NF-kappaB) signal pathway. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | We measured IL-8 mRNA transcripts in H. pylori-infected gastric epithelial cells co-treated with capsaicin by reverse transcriptase-polymerase chain reaction analysis. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | RESULTS: Capsaicin inhibits H. pylori-induced IL-8 production by gastric epithelial cells in dose- and time-dependent manner. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control). | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control). | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | We confirmed that capsaicin inhibited IL-8 mRNA expression after infection of gastric epithelial cells with H. pylori for 6 hours. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 7 | CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 8 | CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 9 | We conclude that capsaicin can be proposed as a potential anti-inflammatory drug by inhibition of the production of IL-8 in H. pylori-infected gastric epithelium. | Capsaicin | C-X-C motif chemokine ligand 8 | Homo sapiens |