Pub. Date : 1991 Dec
PMID : 1774959
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Augmented TPA dependent vector derived c-myc expression was accompanied by enhanced mitogenesis of the cell line FDMT myc.A1 compared with FDC-P1. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | On the other hand, the protein kinase C agonist, TPA, strongly activated c-jun expression but poorly promoted expression (transcription) of c-myc in FDC-P1. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | However, stable transfection of FDC-P1 with a c-myc expression vector driven by a human methallothionein IIA promoter containing the TPA responsive element (TRE), led to a cell clone, FDMT myc.A1, in which TPA mediated selective transcription of the transfected TRE driven c-myc vector and down-regulated expression of the endogenous c-myc gene. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | However, stable transfection of FDC-P1 with a c-myc expression vector driven by a human methallothionein IIA promoter containing the TPA responsive element (TRE), led to a cell clone, FDMT myc.A1, in which TPA mediated selective transcription of the transfected TRE driven c-myc vector and down-regulated expression of the endogenous c-myc gene. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |