Title : Mutational analysis of leucine 47 in human epidermal growth factor.

Pub. Date : 1991 Jul

PMID : 1774224






2 Functional Relationships(s)
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1 Seven site-specific mutants (including changes to other hydrophobic, charged, and heterocyclic amino acids) of leucine 47 of human epidermal growth factor (EGF) were generated by protein engineering and characterized for their activity in three assays: radioreceptor competition binding in membrane fractions, the stimulation of the EGF receptor"s tyrosine kinase activity, and the stimulation of thymidine uptake in tissue culture cells. Thymidine epidermal growth factor Homo sapiens
2 Seven site-specific mutants (including changes to other hydrophobic, charged, and heterocyclic amino acids) of leucine 47 of human epidermal growth factor (EGF) were generated by protein engineering and characterized for their activity in three assays: radioreceptor competition binding in membrane fractions, the stimulation of the EGF receptor"s tyrosine kinase activity, and the stimulation of thymidine uptake in tissue culture cells. Thymidine epidermal growth factor Homo sapiens