Pub. Date : 2007
PMID : 17713972
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Coadministration with small doses of the strong CYP3A4 inhibitor ritonavir results in an increase in darunavir bioavailability from 37% to 82%. | Darunavir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | With regard to the necessary coadministration with low-dose ritonavir as a potent CYP3A4 inhibitor, coadministration of other substrates of CYP3A4 with darunavir/ritonavir requires caution or is even contraindicated. | Darunavir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |