Title : HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation.

Pub. Date : 2007 Sep-Oct

PMID : 17707923






1 Functional Relationships(s)
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1 Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens