Title : Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats.

Pub. Date : 2007 Aug 9

PMID : 17706725






2 Functional Relationships(s)
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1 Nociception induced by histamine was also inhibited by pre-treatment with sodium cromoglycate (800 microg) and by co-administration of the 5-HT(3) receptor antagonist tropisetron (400 mug), while pyrilamine (400 mug) did not inhibit nociception induced by 5-hydroxytryptamine (5-HT, 250 microg) in the TMJ. Histamine 5-hydroxytryptamine receptor 3A Rattus norvegicus
2 It is proposed that histamine activates the H1 receptor to induce the release of 5-HT which depolarizes the nociceptor by activating 5-HT(3) receptor. Histamine 5-hydroxytryptamine receptor 3A Rattus norvegicus