Title : A ferritin-responsive internal ribosome entry site regulates folate metabolism.

Pub. Date : 2007 Oct 12

PMID : 17702748






2 Functional Relationships(s)
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1 Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are elevated by the expression of the heavy chain ferritin (H ferritin) cDNA in cultured cells without corresponding changes in mRNA levels, resulting in enhanced folate-dependent de novo thymidylate biosynthesis and impaired homocysteine remethylation. Folic Acid serine hydroxymethyltransferase 1 Homo sapiens
2 Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are elevated by the expression of the heavy chain ferritin (H ferritin) cDNA in cultured cells without corresponding changes in mRNA levels, resulting in enhanced folate-dependent de novo thymidylate biosynthesis and impaired homocysteine remethylation. Folic Acid serine hydroxymethyltransferase 1 Homo sapiens