Title : Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier.

Pub. Date : 2007 Sep

PMID : 17696988






1 Functional Relationships(s)
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1 The inhibition of p-gp, by valspodar and zosuquidar, increased imatinib uptake (2.5-fold), as did the deficiency of p-gp in Mdr1a/1b(-/-) mice (5.5-fold). valspodar phosphoglycolate phosphatase Mus musculus