Title : Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier.

Pub. Date : 2007 Sep

PMID : 17696988






2 Functional Relationships(s)
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1 Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier. Imatinib Mesylate ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus
2 Perfusing imatinib with the p-gp/Bcrp1 inhibitor, elacridar, enhanced the brain uptake of imatinib in wild-type (4.1-fold) and Mdr1a/1b(-/-) mice (1.2-fold). Imatinib Mesylate ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus