Pub. Date : 2007 Aug
PMID : 17691917
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | So far, the candidate gene approach has provided important clues for pharmacogenomic-based personalized chemotherapy with 6-mercaptopurine (6-MP), solely metabolized by thiopurine S-methyltransferase (TPMT), and irinotecan, mainly detoxified by UDP-glucuronosyltransferase 1A1 (UGT1A1). | Mercaptopurine | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 2 | So far, the candidate gene approach has provided important clues for pharmacogenomic-based personalized chemotherapy with 6-mercaptopurine (6-MP), solely metabolized by thiopurine S-methyltransferase (TPMT), and irinotecan, mainly detoxified by UDP-glucuronosyltransferase 1A1 (UGT1A1). | Mercaptopurine | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 3 | So far, the candidate gene approach has provided important clues for pharmacogenomic-based personalized chemotherapy with 6-mercaptopurine (6-MP), solely metabolized by thiopurine S-methyltransferase (TPMT), and irinotecan, mainly detoxified by UDP-glucuronosyltransferase 1A1 (UGT1A1). | Mercaptopurine | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 4 | So far, the candidate gene approach has provided important clues for pharmacogenomic-based personalized chemotherapy with 6-mercaptopurine (6-MP), solely metabolized by thiopurine S-methyltransferase (TPMT), and irinotecan, mainly detoxified by UDP-glucuronosyltransferase 1A1 (UGT1A1). | Mercaptopurine | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 5 | Reduced activity of TPMT caused by polymorphisms in the TPMT gene and decreased activity of UGT1A1 caused by UGT1A1*28 are related to severe toxic effects of 6-MP and irinotecan, respectively. | Mercaptopurine | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 6 | Reduced activity of TPMT caused by polymorphisms in the TPMT gene and decreased activity of UGT1A1 caused by UGT1A1*28 are related to severe toxic effects of 6-MP and irinotecan, respectively. | Mercaptopurine | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |