Pub. Date : 2007
PMID : 17690563
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity. | Methadone | phosphoglycolate phosphatase | Homo sapiens |
| 2 | Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity. | Methadone | phosphoglycolate phosphatase | Homo sapiens |
| 3 | Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity. | Methadone | phosphoglycolate phosphatase | Homo sapiens |
| 4 | Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1 gene, and whether methadone transport exhibits stereoselectivity. | Methadone | phosphoglycolate phosphatase | Homo sapiens |
| 5 | The intra- to extracellular ratios of methadone, LAAM and their metabolites were all decreased in ABCB1-transfected cells compared to controls (p < 0.05), thus indicating that they are substrates of P-gp. | Methadone | phosphoglycolate phosphatase | Homo sapiens |
| 6 | P-gp may therefore affect the pharmacokinetics and pharmacodynamics of methadone and LAAM. | Methadone | phosphoglycolate phosphatase | Homo sapiens |