Title : Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms.

Pub. Date : 2007 Oct 5

PMID : 17690092






1 Functional Relationships(s)
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1 Of note, pretreatment with antioxidant trolox protects against the inhibitory effect of profound GSH depletion on IKK activation and NF-kappaB nuclear translocation but fails to restore expression of NF-kappaB target genes, revealing both IKK-dependent and -independent inhibition. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus