Title : Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects.

Pub. Date : 2008 Apr

PMID : 17687269






1 Functional Relationships(s)
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1 Our study suggests that the UGT2B7 genotype probably affects lorazepam-valproate pharmacodynamic interaction, especially in subjects who have homovariant genotypes of UGT2B7 and UGT2B15, although the effects on the pharmacokinetics are less significant. Valproic Acid UDP glucuronosyltransferase family 2 member B15 Homo sapiens