Title : A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6.

Pub. Date : 2007 Nov

PMID : 17682072






1 Functional Relationships(s)
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1 In this report, we describe the selectivity of 2-phenyl-2-(1-piperidinyl)propane (PPP) as an inactivator of CYP2B6 and compare this selectivity versus other CYP2B6 inactivators: 1,1",1""-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine. Ticlopidine cytochrome P450 family 2 subfamily B member 6 Homo sapiens