Title : Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells.

Pub. Date : 2007 Jul 27

PMID : 17679938






3 Functional Relationships(s)
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1 Western blot analysis revealed that JWH015 also diminished the level of phosphorylated cofilin in TM cells and this effect of JWH015 was antagonized by SR144528 but not by SR141716A, indicating a CB2 receptor-mediated activation of cofilin. JHW 015 cofilin 1 Homo sapiens
2 Western blot analysis revealed that JWH015 also diminished the level of phosphorylated cofilin in TM cells and this effect of JWH015 was antagonized by SR144528 but not by SR141716A, indicating a CB2 receptor-mediated activation of cofilin. JHW 015 cofilin 1 Homo sapiens
3 This study also shows that JWH015 modulates the activities of Rac1-GTPase and cofilin, which are important signaling molecules for the cytoskeletal and migratory properties of TM cells. JHW 015 cofilin 1 Homo sapiens