Title : Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase.

Pub. Date : 2007 Aug 1

PMID : 17671214






1 Functional Relationships(s)
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1 Exposure of PC-3 and LNCaP cells to apoptosis inducing concentrations of guggulsterone resulted in activation of JNK and p38 mitogen-activated protein kinase (p38 MAPK) in both cell lines and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in LNCaP cells. pregna-4,17-diene-3,16-dione mitogen-activated protein kinase 1 Homo sapiens