Title : Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells.

Pub. Date : 2007 Aug

PMID : 17666793






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens
2 SN-38 decreased p53 expression and increased P-gp expression after 120 h, resulting in inhibition of apoptosis. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens
3 SN-38-induced P-gp expression was additionally enhanced by p53 decoy oligodeoxynucleotide. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens