Pub. Date : 2007
PMID : 17657162
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indeed, nicotine caused oxygen free radical production as well as activation of Rho A and NF-kappaB pathways, evaluated by malondialdehyde levels, pulldown assay and by electrophoretic mobility shift assay, respectively. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Superoxide dimutase, Rho A (Y-27639) and NF-kappaB inhibitors (pyrrolidine dithiocarbamate ammonium, Bay 11-7082) suppressed nicotine effects on CAM expression. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | HMG-CoA reductase inhibitors prevented these nicotine-mediated effects by inhibiting free radical generation and by modulating activation of Rho A and NF-kappaB pathways. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |