Title : Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta.

Pub. Date : 2008 Feb

PMID : 17654516






2 Functional Relationships(s)
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1 PKC-alpha expression and phosphorylation were almost completely downregulated under combined treatment with TGF-beta + TPA at 24 and 72 h, as shown by immunoblots. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
2 Confocal microscopy demonstrated that TGF-beta-induced nuclear accumulation of PKC-alpha was abolished in the presence of TPA at the same time points. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens