Pub. Date : 2007 Apr
PMID : 17651610
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To observe the induction of cell transdifferentiation, connective tissue growth factor (CTGF) expression and collagen production of human lung fibroblast (HLF) by angiotensin II (Ang II), and to investigate the inhibitory effect of Ang II receptor antagonist-losartan on this process. | Losartan | angiotensinogen | Homo sapiens |
| 2 | RESULTS: In the Ang II group, CTGF mRNA level (0.82 +/- 0.07) was significantly higher than the control group (0.29 +/- 0.05), the Ang II + Losartan group (0.51 +/- 0.04) and the Losartan group (0.26 +/- 0.04). | Losartan | angiotensinogen | Homo sapiens |
| 3 | RESULTS: In the Ang II group, CTGF mRNA level (0.82 +/- 0.07) was significantly higher than the control group (0.29 +/- 0.05), the Ang II + Losartan group (0.51 +/- 0.04) and the Losartan group (0.26 +/- 0.04). | Losartan | angiotensinogen | Homo sapiens |
| 4 | Alpha-SMA expression level (0.85 +/- 0.09) and Col I mRNA (0.20 +/- 0.02) of Losartan + Ang II co-incubated antisense oligonucleotide transfected HLF cells decreased significantly as compared to Ang II treated alone. | Losartan | angiotensinogen | Homo sapiens |
| 5 | Losartan blocked Ang II induced HLF cell transdifferentiation and collagen production. | Losartan | angiotensinogen | Homo sapiens |