Title : Comparative QSAR modeling of COX-2 inhibitor 1,2-diarylimidazoles using E-state and physicochemical parameters.

Pub. Date : 2007 Jun

PMID : 17650586






1 Functional Relationships(s)
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1 Also, an amino substituent is preferred over a methyl group at R2 position suggesting preference of the sulfonamide moiety over the methyl sulfone moiety for the COX-2 binding affinity. Sulfonamides mitochondrially encoded cytochrome c oxidase II Homo sapiens