Pub. Date : 2007 Oct 12
PMID : 17646170
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem, and retinal neurons. | polyglutamine | ataxin 7 | Mus musculus |
| 2 | Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem, and retinal neurons. | polyglutamine | ataxin 7 | Mus musculus |
| 3 | Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem, and retinal neurons. | polyglutamine | ataxin 7 | Mus musculus |
| 4 | Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem, and retinal neurons. | polyglutamine | ataxin 7 | Mus musculus |
| 5 | Site-directed mutagenesis of these two caspase-7 cleavage sites in the polyQ-expanded form of ataxin-7 produces an ataxin-7 D266N/D344N protein that is resistant to caspase cleavage. | polyglutamine | ataxin 7 | Mus musculus |
| 6 | Site-directed mutagenesis of these two caspase-7 cleavage sites in the polyQ-expanded form of ataxin-7 produces an ataxin-7 D266N/D344N protein that is resistant to caspase cleavage. | polyglutamine | ataxin 7 | Mus musculus |
| 7 | We also detected N-terminal polyQ-expanded ataxin-7 cleavage products in SCA7 transgenic mice similar in size to those generated by caspase-7 cleavage. | polyglutamine | ataxin 7 | Mus musculus |
| 8 | We also detected N-terminal polyQ-expanded ataxin-7 cleavage products in SCA7 transgenic mice similar in size to those generated by caspase-7 cleavage. | polyglutamine | ataxin 7 | Mus musculus |
| 9 | In a SCA7 transgenic mouse model, recruitment of caspase-7 into the nucleus by polyQ-expanded ataxin-7 correlated with its activation. | polyglutamine | ataxin 7 | Mus musculus |
| 10 | In a SCA7 transgenic mouse model, recruitment of caspase-7 into the nucleus by polyQ-expanded ataxin-7 correlated with its activation. | polyglutamine | ataxin 7 | Mus musculus |