Pub. Date : 2007 Jul 15
PMID : 17638885
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | Treatment with metformin selectively suppressed the tumor growth of HCT116 p53(-/-) xenografts. | Metformin | tumor protein p53 | Homo sapiens |
| 3 | Following treatment with metformin, we detected increased apoptosis in p53(-/-) tumor sections and an enhanced susceptibility of p53(-/-) cells to undergo apoptosis in vitro when subject to nutrient deprivation. | Metformin | tumor protein p53 | Homo sapiens |
| 4 | Following treatment with metformin, we detected increased apoptosis in p53(-/-) tumor sections and an enhanced susceptibility of p53(-/-) cells to undergo apoptosis in vitro when subject to nutrient deprivation. | Metformin | tumor protein p53 | Homo sapiens |
| 5 | Treatment with either metformin or AICAR also led to enhanced fatty acid beta-oxidation in p53(+/+) MEFs, but not in p53(-/-) MEFs. | Metformin | tumor protein p53 | Homo sapiens |
| 6 | Metformin-treated cells compensated for this suppression of oxidative phosphorylation by increasing their rate of glycolysis in a p53-dependent manner. | Metformin | tumor protein p53 | Homo sapiens |
| 7 | Together, these data suggest that metformin treatment forces a metabolic conversion that p53(-/-) cells are unable to execute. | Metformin | tumor protein p53 | Homo sapiens |
| 8 | Thus, metformin is selectively toxic to p53-deficient cells and provides a potential mechanism for the reduced incidence of tumors observed in patients being treated with metformin. | Metformin | tumor protein p53 | Homo sapiens |
| 9 | Thus, metformin is selectively toxic to p53-deficient cells and provides a potential mechanism for the reduced incidence of tumors observed in patients being treated with metformin. | Metformin | tumor protein p53 | Homo sapiens |