Title : Effects of capsaicin on VGSCs in TRPV1-/- mice.

Pub. Date : 2007 Aug 13

PMID : 17632091






4 Functional Relationships(s)
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1 Two different mechanisms by which capsaicin blocks voltage-gated sodium channels (VGSCs) were found by using knockout mice for the transient receptor potential V1 (TRPV1(-/-)). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 The selective effect of low concentration capsaicin on VGSCs was reversed in TRPV1(-/-) mice, which suggested that this effect was dependent on TRPV1 receptor. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 The selective effect of low concentration capsaicin on VGSCs was reversed in TRPV1(-/-) mice, which suggested that this effect was dependent on TRPV1 receptor. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
4 The blockage effect of high concentration capsaicin on VGSCs in TRPV1(-/-) mice was the same as that in capsaicin insensitive neurons of rats and TRPV1(+/+) mice. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus