Pub. Date : 2007 Apr-Jun
PMID : 17624242
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study we report that the most potent P2X(7) receptor agonist BzATP stimulates the expression of the metabotropic ATP receptor P2Y(2) in cultured rat brain astrocytes. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2Y2 | Rattus norvegicus |
| 2 | Here we present evidence that P2Y(2) mRNA expression in cultured astrocytes peaks 6 h after BzATP exposure and returns to basal levels after 24 h. This effect was mimicked by high ATP concentrations (1 mM) and was abolished by P2X(7)-antagonists oATP and BBG. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2Y2 | Rattus norvegicus |
| 3 | The BzATP-evoked P2Y(2) receptor up-regulation in cultured astrocytes was coupled to an increased UTP-mediated intracellular calcium response. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2Y2 | Rattus norvegicus |
| 4 | Each inhibitor significantly reduced the extent to which BzATP induced P2Y(2) mRNA. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2Y2 | Rattus norvegicus |