Pub. Date : 2007 Jul
PMID : 17620218
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Of six cDNA-expressed human P450 enzymes tested, CYP2B6 and CYP1A2, followed by CYP3A4, had high catalytic activities at a 20 microM propofol concentration, corresponding to clinical plasma levels. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | K(m) and k(cat) values for propofol omega- and 4-hydroxyation were 27 microM and 21 nmol omega-hydroxypropofol formed/min/nmol CYP2B6 and 30 microM and 42 nmol 4-hydroxypropofol formed/min/nmol CYP2B6, respectively. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | K(m) and k(cat) values for propofol omega- and 4-hydroxyation were 27 microM and 21 nmol omega-hydroxypropofol formed/min/nmol CYP2B6 and 30 microM and 42 nmol 4-hydroxypropofol formed/min/nmol CYP2B6, respectively. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | CYP2B6 expressed in HepG2 cells also effectively catalyzed propofol omega- and 4-hydroxylation. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | In a panel of individual human liver microsomes, propofol omega- and 4-hydroxylation activities (at the substrate concentration of 20 microM) were highly correlated with CYP2B6 contents, and moderately with CYP3A4 contents. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | These results suggest that CYP2B6 has an important role in propofol omega- and 4-hydroxylation in human livers and that the hepatic contents of CYP2B6, CYP3A4, and CYP1A2 determine which P450 enzymes play major roles in propofol oxidation in individual humans. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 8 | These results suggest that CYP2B6 has an important role in propofol omega- and 4-hydroxylation in human livers and that the hepatic contents of CYP2B6, CYP3A4, and CYP1A2 determine which P450 enzymes play major roles in propofol oxidation in individual humans. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 9 | These results suggest that CYP2B6 has an important role in propofol omega- and 4-hydroxylation in human livers and that the hepatic contents of CYP2B6, CYP3A4, and CYP1A2 determine which P450 enzymes play major roles in propofol oxidation in individual humans. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |