Title : Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever.

Pub. Date : 2007 Jul

PMID : 17610314






8 Functional Relationships(s)
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1 Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
2 Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
3 Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1 or MDR1) is a drug transporter that extrudes colchicine out of cells. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
4 Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1 or MDR1) is a drug transporter that extrudes colchicine out of cells. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
5 Thus, the amount of MDR1 in mononuclear cells may alter response to colchicine. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
6 We investigated the association between MDR1 3435C to T polymorphism and colchicine response in patients with FMF. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
7 Patients with the TT genotype for the ABCB1 3435C to T variant responded better to colchicine in terms of treatment efficacy and colchicine dose requirements. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
8 Patients with the TT genotype for the ABCB1 3435C to T variant responded better to colchicine in terms of treatment efficacy and colchicine dose requirements. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens