Title : XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.

Pub. Date : 2007 Jul

PMID : 17603793






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, depletion of XRCC1 resulted in a significantly increased sensitivity to the alkylating agent methyl methanesulfonate and the thymidine base analog 5-hydroxymethyl-2"-deoxyuridine, a slightly increased sensitivity to ethyl methanesulfonate and 1,3-bis(2-chloroethyl)-1-nitrosourea, and no change in the response to camptothecin. Methyl Methanesulfonate X-ray repair cross complementing 1 Homo sapiens