Pub. Date : 1991 Oct
PMID : 1759822
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential modulation of cytokine production by macrolides: interleukin-6 production is increased by spiramycin and erythromycin. | Erythromycin | interleukin 6 | Homo sapiens |
| 2 | We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide. | Erythromycin | interleukin 6 | Homo sapiens |
| 3 | Spiramycin and, to a lesser extent, erythromycin increased total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production, whereas roxithromycin had no effect. | Erythromycin | interleukin 6 | Homo sapiens |