Pub. Date : 2007 Aug 17
PMID : 17591779
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPA stimulation targets TRIP6 to the focal adhesion complexes and promotes c-Src-dependent phosphorylation of TRIP6 at Tyr-55, which creates a docking site for the Crk Src homology 2 domain, thereby promoting LPA-induced morphological changes and cell migration. | lysophosphatidic acid | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Here we further demonstrate that a switch from c-Src-mediated phosphorylation to PTPL1/Fas-associated phosphatase-1-dependent dephosphorylation serves as an inhibitory feedback control mechanism of TRIP6 function in LPA-induced cell migration. | lysophosphatidic acid | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |