Title : Back to the future: COX-2 inhibitors for chemoprevention and cancer therapy.

Pub. Date : 2007 Jun

PMID : 17584158






2 Functional Relationships(s)
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Protein Name
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1 Several cytokines, reactive oxygen species (ROS) and mediators of inflammatory pathway such as activation of nuclear factor-kappaB (NF-kappaB) and COX-2 leads to an increase in cell proliferation, survival, and inhibition of pro-apoptotic pathway, ultimately resulting in tumor angiogenesis, invasion and metastasis. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Several cytokines, reactive oxygen species (ROS) and mediators of inflammatory pathway such as activation of nuclear factor-kappaB (NF-kappaB) and COX-2 leads to an increase in cell proliferation, survival, and inhibition of pro-apoptotic pathway, ultimately resulting in tumor angiogenesis, invasion and metastasis. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens