Title : Fluconazole coadministration concurrent with cyclophosphamide conditioning may reduce regimen-related toxicity postmyeloablative hematopoietic cell transplantation.

Pub. Date : 2007 Jul

PMID : 17580253






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Fluconazole inhibits cytochrome P450 2C9, which is involved with the activation of CY, and so might provide protection from CY-related toxicities. Cyclophosphamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Fluconazole inhibits cytochrome P450 2C9, which is involved with the activation of CY, and so might provide protection from CY-related toxicities. Cyclophosphamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 These data support the hypothesis that fluconazole, when coadministered with CY, decreases CY-related toxicities by inhibiting cytochrome P450 2C9 metabolism. Cyclophosphamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens