Title : Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.

Pub. Date : 2007 Jun 20

PMID : 17579717






3 Functional Relationships(s)
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1 Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry. Capsaicin calmodulin 1 Rattus norvegicus
2 Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry. Capsaicin calmodulin 1 Rattus norvegicus
3 Camstatin, a selective peptide blocker of calmodulin, inhibits vanilloid-induced Ca(2+)-uptake in intact TRPV1(+) cells, and suggests an extracellular site of inhibition. Capsaicin calmodulin 1 Rattus norvegicus