Title : Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome.

Pub. Date : 2007 Jul 3

PMID : 17576861






1 Functional Relationships(s)
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1 Treatment with the protein synthesis inhibitor cycloheximide or RNA interference-mediated knockdown of the Upf1 protein resulted in the restoration of mutant mRNA to levels comparable to that of the wild-type minigene, suggesting that hERG nonsense mutations are subject to nonsense-mediated mRNA decay. Cycloheximide UPF1 RNA helicase and ATPase Homo sapiens