Pub. Date : 2007 Jun 15
PMID : 17575157
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We show in this study that the endoplasmic reticulum (ER) stress inducer, tunicamycin, selectively up-regulated the cell surface expression of TRAIL-R2, but not other members of the TNF receptor family, and enhanced TRAIL-induced apoptosis in cultured melanoma cells and fresh melanoma isolates. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
2 | Tunicamycin-mediated sensitization of melanoma cells to TRAIL-induced apoptosis was associated with increased activation of the caspase cascade and reduction in mitochondrial membrane potential and was inhibited by a recombinant TRAIL-R2/Fc chimeric protein. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |