Title : Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.

Pub. Date : 2007 May

PMID : 17573710






5 Functional Relationships(s)
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1 Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures. Benzo(a)pyrene JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied. Benzo(a)pyrene JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied. Benzo(a)pyrene JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 Conversely to NF-kappaB activation the transcription factor AP-1 was activated in the hepatoma HepG2 cells by cell treatment with BP but not in the hepatoma 27 cells. Benzo(a)pyrene JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
5 The transcription factor AP-1 seems to be activated as a result of the interaction of BP with the Ah-receptor. Benzo(a)pyrene JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens