Title : Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA.

Pub. Date : 2007 Jul

PMID : 17570247






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Oxidation of E(2) to 2-OHE(2) is mainly catalyzed by cytochrome P450 (CYP) 1A1, and CYP3A4, whereas oxidation of E(2) to 4-OHE(2) in extrahepatic tissues is mainly catalyzed by CYP1B1 as well as some CYP3As. Estradiol cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Oxidation of E(2) to 2-OHE(2) is mainly catalyzed by cytochrome P450 (CYP) 1A1, and CYP3A4, whereas oxidation of E(2) to 4-OHE(2) in extrahepatic tissues is mainly catalyzed by CYP1B1 as well as some CYP3As. Estradiol cytochrome P450 family 3 subfamily A member 4 Homo sapiens