Title : Cyclic AMP-dependent, protein kinase A-independent activation of extracellular signal-regulated kinase 1/2 following adenosine receptor stimulation in human umbilical vein endothelial cells: role of exchange protein activated by cAMP 1 (Epac1).

Pub. Date : 2007 Sep

PMID : 17565009






2 Functional Relationships(s)
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Protein Name
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1 Overexpression of Epac1 enhanced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation, whereas response to VEGF was unaffected. Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens
2 Inhibition of Epac1 expression with small interfering RNA substantially reduced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation and abolished that by 8CPT-2Me-cAMP. Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens