Title : A combination of IFN-beta and temozolomide in human glioma xenograft models: implication of p53-mediated MGMT downregulation.

Pub. Date : 2008 Apr

PMID : 17564708






2 Functional Relationships(s)
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1 In our previous experiments, we observed that IFN-beta sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to attenuation of MGMT expression via induction of TP53. Temozolomide interferon beta 1 Homo sapiens
2 In this context, IFN-beta inactivates MGMT via p53 gene induction and enhances the therapeutic efficacy to TMZ. Temozolomide interferon beta 1 Homo sapiens