Title : Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.

Pub. Date : 2007 Sep 1

PMID : 17556716






1 Functional Relationships(s)
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1 MEASUREMENTS AND MAIN RESULTS: Intravenous administration of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), a selective glycogen synthase kinase-3beta inhibitor, significantly inhibited ovalbumin-induced increases in total cell counts, eosinophil counts, and IL-5, IL-13, and eotaxin levels recovered in bronchoalveolar lavage fluid in a dose-dependent manner. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione glycogen synthase kinase 3 beta Mus musculus