Pub. Date : 2007 Jun
PMID : 17551816
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |
| 2 | O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |