Title : Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling.

Pub. Date : 2007 Nov

PMID : 17551669






2 Functional Relationships(s)
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1 The intracellular calcium chelator, BAPTA-AM, was shown to block PGE2-induced Erk and EGFR phosphorylation. Dinoprostone epidermal growth factor receptor Homo sapiens
2 Our findings suggest that in human cholangiocarcinoma cells, PGE2-enhanced phosphorylation of Erk is, at least in part, mediated through EP1 receptors and EGFR phosphorylation induced by increases in the intracellular concentration of calcium. Dinoprostone epidermal growth factor receptor Homo sapiens