Title : Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.

Pub. Date : 2007 Jul

PMID : 17549408






1 Functional Relationships(s)
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1 Animals of the aspirin/DFMO group exhibited an inactivation of ornithine decarboxylase, a key enzyme in polyamine biosynthesis, and a two-fold reduction in the prostaglandin E2 content of the colonic mucosa (p<0.01). Eflornithine ornithine decarboxylase 1 Rattus norvegicus