Pub. Date : 2007 Jun
PMID : 17548664
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial. | Nicotine | catechol-O-methyltransferase | Homo sapiens |
| 2 | The genotype x treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). | Nicotine | catechol-O-methyltransferase | Homo sapiens |
| 3 | Our results indicate that COMT genotype may moderate the effect of active transdermal nicotine patch compared with placebo, with reduced relative benefit of nicotine replacement therapy in individuals with Met/Val or Val/Val genotype. | Nicotine | catechol-O-methyltransferase | Homo sapiens |