Title : Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation.

Pub. Date : 2007 Jun 1

PMID : 17545612






1 Functional Relationships(s)
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1 As evidenced by increased Ser(139)-phosphorylated histone H2AX (gammaH2AX), impaired Ku70 function diminished cellular capability to repair DNA DSBs induced by bleomycin, doxorubicin, and etoposide, thereby enhancing their cell-killing effect. Bleomycin X-ray repair cross complementing 6 Homo sapiens